The ACQUITY Premier System minimizes metal-sensitive analyte loss, improving recovery, and limits of detection. Couple the ACQUITY Premier System with a Waters Mass Spectrometer to confidently identify and quantify unknown compounds in complex samples and confirm trace components at the lowest possible levels.

Fifty-four percent reduction in peak tailing leads to better detection of deamidation impurities. T37: GFYPSDIAVEWESNGQPENNYK.

• MaxPeak High Performance Surface technology increases analyte recovery, sensitivity, and reproducibility by minimizing analyte/surface interactions that can lead to sample losses.
• Get the flexibility of multi-solvent blending with the Quaternary Solvent Manager (QSM), and blend four solvents in any combination or proportion. Expand to up to nine solvents with the optional and integrated solvent-select valve for even greater flexibility. Automated solvent compressibility allows you to run any solvent in any combination without loss in accuracy or precision.
• Deliver precise and accurate binary solvent blending with the Binary Solvent Manager (BSM) at pressures up to 15,000 psi. Two integrated solvent-select valves provide access to a total of four solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability.
• High-precision injections with direct inject sampling. The needle-in-flow path design ensures an accurate needle seal at high pressure. Injection volumes from 0.1 μL up to 1 mL are supported. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers.
• Accurate temperature control across the entire column. Configurable for one to six columns, each housed in individual temperature-controlled zones with active pre-heating and a temperature range of 4 to 90 °C.
• Low-dispersion detection capabilities. Minimizing dispersion and optimizing the electronics and optical paths for the narrow UPLC peaks yields the highest sensitivity and repeatability with the most accurate quantification.
• Significantly reduce the time you spend in the prep lab by automating the formulation of mobile phases at specific pH and ionic strength from reservoirs of pure solvents or concentrated stock solutions using Auto•Blend Plus Technology, available with the ACQUITY Premier Quaternary System.
• Automatically manage gradient start time and pre-injection steps in parallel with SmartStart technology. This allows you to compensate for system volume differences when transferring methods between different LC systems or to minimize inject-to-inject cycle times for high-throughput applications.
• Gradient SmartStart easily adjusts for system volume differences when transferring methods from an alternative LC system without alteration to the method table.
• Supported in Empower, Masslynx, and UNIFI softwares.