MaxPeak Premier Columns

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MaxPeak Premier Columns are designed to be the most universal column platform for chromatographers who need to reduce variability risks and save time, while increasing recovery and sensitivity. Non-specific adsorption (NSA) of metal sensitive compounds is an unpredictable challenge, leading to long column passivation times, chromatography with large RSDs, and broad peaks that can be a challenge to detect.

MaxPeak Premier Columns feature MaxPeak High Performance Surfaces (HPS) which effectively reduce NSA losses due to metal interactions and provide:

Reduced column passivation
Increased reproducibility
Enhanced sensitivity
Improved peak shapes

Reduce the risks associated with unpredictable chromatography. See and do more with MaxPeak Premier Columns.

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Overview

Literature

Application Notes

Support

Column Brands

	ACQUITY Premier Columns Harness the power of sub-2-μm particles with ACQUITY Premier Columns. Achieve increases in resolution, sensitivity, accuracy, speed, reliability, and robustness. Learn more
	Atlantis Premier Columns Analytical columns for stable polar compound retention of broad analyte mixtures. Learn more
	DNA/RNA Oligonucleotide Separations Waters oligonucleotide columns contain second-generation, hybrid-silica BEH Technology particles functionalized with C18. Learn more
	HILIC for Large Biomolecules It is possible to use HILIC to glean previously unattainable information for intact proteins (with or without glycosylation), protein fragments, and complext, released glycans. Learn more
	HILIC for Released Glycans ACQUITY UPLC and XBridge Glycan BEH Amide 130 Å Columns are best suited for the analysis of released, N-labeled glycans using pre-column labeling with 2-AB, 2-AA, or Waters innovative and enabling RapiFluor-MS reagent. Learn more
	MaxPeak Premier SEC Protein Columns Efficiently separate protein-size variants from simple-to-complex biotherapeutics (approximately 10,000 to 650,000 Da) in a single SEC anaysis for reliable component quantitation using a platform method. Learn more
	Mixed Mode for Released Glycans Glycan BEH C18 AX Columns are packed with a mixed-mode, reversed-phase/anion-exchange chemistry that separates acidic glycans by charge and hydrophobic interactions which provide orthogonal selectivity to HILIC amide columns. Learn more
	Peptide Reversed-Phase Columns Reversed-phase chromatography using ion-pairing reagents such as TFA and formic acid can deliver highly resolved separations of complex peptide mixtures. Learn more
	XBridge Premier 2.5 µm Columns Utilizing BEH particle technology, these columns are built to withstand high pH, high termperatures, and other extreme operating conditions. Learn more
	XSelect Premier 2.5 µm Columns These CSH (Charged Surface Hybrid) and HSS (High-Strength Silica) particle based columns provide unique selectivity, and deliver operational stability and method scalability. Learn more

Column Selection

Simply choose the base particle, ligand, and particle size that fits your needs.

<2 µm particles to fully mazimize chromatographic separations and sensitivity
For Small Molecule Analysis	For Large Molecule Analysis
ACQUITY Premier BEH C18 Columns	ACQUITY Premier Glycan BEH Amide, 130 Å Columns
ACQUITY Premier HSS T3 Columns	ACQUITY Premier Glycan BEH C18 AX, 95 Å Columns
ACQUITY Premier CSH C18 Columns	ACQUITY Premier Glycoprotein BEH Amide, 300 Å Columns
ACQUITY Premier CSH Phenyl-Hexyl Columns	ACQUITY Premier Oligonucleotide BEH C18, 130 Å Columns
ACQUITY Premier BEH Amide Columns	ACQUITY Premier Peptide BEH C18, 130 Å and 300 Å Columns
ACQUITY Premier BEH Shield RP18 Columns	ACQUITY Premier Peptide CSH C18, 130 Å Columns
Atlantis Premier BEH C18 AX Columns	ACQUITY Premier Peptide HSS T3, 100 Å Columns
Atlantis Premier BEH Z-HILIC Columns	ACQUITY Premier Protein BEH C4, 300 Å Columns
	ACQUITY Premier Protein BEH SEC, 250 Å Columns

>2 µm particles to provide a perfect compromise between chromatographic performance and lower backpressures
For Small Molecule Analysis	For Large Molecule Analysis
XBridge Premier BEH Amide Columns	XBridge Premier Oligonucleotide BEH C18, 130 Å Columns
XBridge Premier BEH C18 Columns	XBridge Premier Peptide BEH C18, 130 Å and 300 Å Columns
XBridge Premier BEH Shield RP18 Columns	XBridge Premier Peptide CSH C18, 130 Å Columns
XSelect Premier CSH C18 Columns	XBridge Premier Peptide HSS T3, 100 Å Columns
XSelect Premier CSH Phenyl-Hexyl Columns	XBridge Premier Protein BEH C4, 300 Å Columns
XSelect Premier HSS T3 Columns	XBridge Premier Protein BEH SEC, 250 Å Columns
Atlantis Premier BEH C18 AX Columns
Atlantis Premier BEH Z-HILIC Columns