Electron Capture Dissociation (ECD)
Comprehensive characterization and analysis of complex biomolecules requires more than just CID-derived data, and that’s why the SELECT SERIES Cyclic IMS now offers two new exciting fragmentation techniques: Electron Capture Dissociation (ECD) in partnership with e-MSion, Inc. (Portland, Oregon) and Surface Induced Dissociation (SID) in collaboration with Prof. Vicki Wysocki from The Ohio State University.
ECD is initiated by electron attachment/transfer to multiply-protonated molecules, which induces cleavage at N–Cα bonds, in a peptide backbone. ECD preserves unstable side-chain modifications during fragmentation and generates complementary data to CID providing more detailed structural information, increased sequence coverage and greater confidence for more complete characterization of proteins, PTMs, and glycans.