A greener approach to high throughput purification

The SFC Prep 150 Mgm System has a maximum flow rate, CO₂ and co-solvent combined, up to 150 mL/minute allowing use of 19 mm and 30 mm columns. It also has capacity for six fraction collection positions (two liters each).

Controlled by the Waters Chromscope 2.1 SFC Software running under Windows 10, the user can take advantage of a new intuitive graphical interface. The SFC Prep 150 Mgm System operates at flow rates higher than traditional HPLC systems without significant increases in back pressure, allowing for high-speed SFC purification and improved resolution of compounds, leading to higher purity isolations. ChromScope v2.1 is an updated version of ChromScope Software that enables support of the Waters SFC Prep 150 Mgm System with the ACQUITY QDa Mass Detector. Additionally, this update adds support for ELSD and the ISM.

The Waters SFC Prep 150 Mgm System is perfectly suited for laboratories seeking to adopt a greener approach to high throughput purification. The SFC Prep 150 Mgm System is the ideal choice when reduction of normal-phase solvent usage and disposal is a critically important step for purification laboratories wanting to become more environmentally friendly

SFC systems utilize liquid carbon dioxide (CO₂) as its main mobile phase in combination with one or more organic solvents resulting in faster equilibration, lower pressure drops across the column, solvent reduction and lower cost per sample.  The process is reproducible and applicable to a wide range of compounds relevant in the Pharmaceutical, Life Sciences, Chemical Materials and Food & Environmental markets.

System features

QGM Low Pressure mixing Quaternary Gradient Pump:  This pump delivers flowrates up to a maximum of 150mL/min serves as the co-solvent delivery device for this system.

P200X CO₂ Pump:  This is a high pressure delivery pump having dual stainless steel heads with a cam driven sapphire piston assembly; self priming check valves; presser sensor; pressure gauge; brushless motor and a rupture disc assembly. The pumps design lends itself to control based upon feedback from the pressure sensor and mass flowmeter.

Modifier Stream Injector: This design supports customers requests of Modified Stream Injection ONLY.  It's function is to inject one sample at a time using a standard 2-mL loop and a 5-mL syringe.  This device allows for settable air gaps on either side of the sample. The air gap functions as a buffer between the solvent and the sample decreasing dilution.   

Prep Collection Cabinet: This collection cabinet comes with a retractable front door allowing for easy insertion and removal of 2-Liter Fraction Bottles.  It has an exhaust port located in the upper backside of the cabinet to easily fit laboratories around the world requiring exhaust. It comes standard with a removable spill tray. 

Effortless Integration with the ACQUITY QDa Mass Detector: The intuitive design of the ACQUITY QDa Mass Detector gives you the additional data you need without the cost and complexity of traditional mass spectrometry. Now you can have access to the analytical confidence from the selectivity that mass detection brings to your analysis.