Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs! Waters offers a comprehensive range of analytical system solutions, software, and services for scientists. Liquid Chromatography. Mass Spectrometry. Waters is the leading provider of lab equipment, supplies and software for scientists across the world. Easily research and order everything your lab needs!
High Sensitivity Bioanalysis using the Waters™ Xevo™ TQ Absolute Tandem Quandrupole Mass Spectrometer
This application brief demonstrates the reproducible, robust sensitivity achievable using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer as part of a UPLC-MS/MS system for bioanalytical studies. Sensitivity limits as low as 250 ag (0.25 femtograms) of midazolam and mipramine were detected on-column from a matrix sample (rat plasma) using a rudimentary, generic sample preparation technique (protein precipitation). This level of sensitivity was demonstrated to be reproducible and robust with limits of quantification determined to be 0.2 g/mL for both compounds.
