Emerging Modalities in DMPK

Emerging Modalities in DMPK

Efficiently adapt to new analytical challenges to determine DMPK properties of emerging therapeutic classes, including PROteolysis-Targeting Chimeras (PROTACs), with Waters UPLC-MS/MS solutions. Stay ahead of the bioanalysis requirements in an evolving DMPK landscape with exceptional sensitivity, accuracy, and reliability from Waters advanced chromatography, mass spectrometry, and sample preparation tools.

Efficiently adapt to new analytical challenges to determine DMPK properties of emerging therapeutic classes, including PROteolysis-Targeting Chimeras (PROTACs), with Waters UPLC-MS/MS solutions. Stay ahead of the bioanalysis requirements in an evolving DMPK landscape with exceptional sensitivity, accuracy, and reliability from Waters advanced chromatography, mass spectrometry, and sample preparation tools.
Peptide molecular structure in blue
Peptide molecular structure in blue

Overview

Next-generation small molecule medicines like PROTACs offer potential solutions for previously untreatable diseases, and accurately measuring their DMPK properties is crucial for drug discovery and development. Due to their long half-lives and low systemic concentrations, high-sensitivity bioanalysis is essential.

Waters UPLC-MS/MS and advanced chromatography solutions, sample preparation kits, standards, and high-sensitivity mass spectrometry systems simplify method development and ensure high-quality quantitative bioanalysis assays across modality types—supporting the evolution of safe and effective medicines. 

Applications

PROTACs molecules are a new class of drug molecules with the potential to treat many diseases. Discover how Waters addresses the challenges associated with PROTACs analysis in DMPK studies with these application notes.

PROTACs molecules are a new class of drug molecules with the potential to treat many diseases. Discover how Waters addresses the challenges associated with PROTACs analysis in DMPK studies with these application notes.

Application Notes

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape

Expand your capabilities across evolving modalities with Waters compendium of the latest applications in quantitative bioanalysis. The notebook features application notes covering a range of bioanalytical topics, including small molecule therapeutics, oligonucleotide therapeutics, peptide/protein therapeutics, efficiency enabling software, and novel imaging approaches. Learn how Waters can help you overcome the challenges brought by these new and varied drug modalities.

Expand your capabilities across evolving modalities with Waters compendium of the latest applications in quantitative bioanalysis. The notebook features application notes covering a range of bioanalytical topics, including small molecule therapeutics, oligonucleotide therapeutics, peptide/protein therapeutics, efficiency enabling software, and novel imaging approaches. Learn how Waters can help you overcome the challenges brought by these new and varied drug modalities.
Download Application Notebook
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Solutions

Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of PROTACs and other emerging modality pharmaceuticals. 

Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of PROTACs and other emerging modality pharmaceuticals. 

Absolute performance for lowest levels of quantification

Absolute performance for lowest levels of quantification
Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

Achieve and maintain high performance and productivity with significantly increased sensitivity for negative ionizing compounds with the Xevo TQ Absolute Triple Quadrupole Mass Spectrometer, Waters compact, sustainable tandem quadrupole mass spectrometer for confident detection and quantification of drugs and metabolites. 

  • PROTACs Bioanalysis

High performance chromatography for new bioanalytical challenges

High performance chromatography for new bioanalytical challenges
ACQUITY Premier System

Optimize chromatographic resolution and speed while eliminating concerns of non-specific binding for new analytes with the Waters ACQUITY Premier UPLC System and enhance overall quantitative performance in bioanalysis assays.

  • PROTACs Bioanalysis

Market-leading versatility and flexibility for bioanalytical challenges

Market-leading versatility and flexibility for bioanalytical challenges
MassLynx Mass Spectrometry Software

MassLynx Software Solutions enables users to better leverage their MS systems and harness real-time intelligence, ensure MS system performance, and more quickly convert sample data into valuable knowledge for bioanalysis assays.

  • PROTACs Bioanalysis

Quality consumables to support your success.

Quality consumables to support your success.

Stop looking and start seeing – no compromise required

Stop looking and start seeing – no compromise required
ACQUITY Premier Columns

Develop the most sensitive reliable and high-performance bioanalysis methods and reduce risks associated with non-specific binding in new modality classes with ACQUITY Premier Columns with MaxPeak High Performance Surfaces (HPS) Technology. 

  • PROTACs Bioanalysis

Faster, simpler, more effective sample preparation for the bioanalysis of novel modalities

Faster, simpler, more effective sample preparation for the bioanalysis of novel modalities
Oasis Solid-Phase Extraction (SPE) Products

Meet a wide variety of sample preparation needs, from simple and fast sample matrix clean-up to more complex sample preparation challenges with Oasis SPE products that deliver unmatched purity, consistency, and quality for sample analysis. 

  • PROTACs Bioanalysis

A simpler way to cleaner samples

A simpler way to cleaner samples
Ostro Pass-Through Sample Preparation Products

Eliminate time-consuming or complicated sample preparation with Ostro Pass-Through Sample Preparation Products, which provide a simple solution for phospholipid and protein removal from biological samples and require minimal to no method development.

  • PROTACs Bioanalysis
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Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Your success is just a click away

Your success is just a click away
Waters Global Services

Optimize your laboratory's productivity and success with Waters Global Services. Maintain peak system performance, minimize downtime, address application challenges, and support stringent compliance requirements.

  • PROTACs Bioanalysis

Make science more accessible with Waters Capital

Make science more accessible with Waters Capital
Payment Solutions

Optimize chromatographic resolution and speed while eliminating concerns of non-specific binding for new analytes with the Waters ACQUITY Premier UPLC System and enhance overall quantitative performance in bioanalysis assays.

  • PROTACs Bioanalysis

The data speaks for itself

The data speaks for itself
Comparison of chromatographic peak shape for PROTACs 3 gefitinib using ACQUITY Premier chromatography system/column and Conventional UPLC system/column, with reduced trailing and Peak width at base (Pwb) improvements shown.
Pharmacokinetics elimination curve of PROTACS 3 gefitinib determined by ACQUITY Premier with Xevo TQ Absolute for quantitation, following subcutaneous administration to the male Wistar rat at 10 mg/kg.
0.5 pg/mL PROTACs – 3- gefitinib in rat plasma.
Positive ion LC-MS/MS analysis of gefitinib based PROTACs-3, gefitinib-d6 and gefitinib using a 2.1 x 50 mm ACQUITY HSS T3 1.7 µm C18 Column, maintained at 60 °C and eluted with a 5–95% aqueous – acetonitrile 1 mM ammonium formate, 0.1% formic acid gradient over 2 minutes with a 2 minute hold.

Webinars and Resources

  • On Demand Webinar

High Throughput Quantification of Gefitinib-3-PROTACs and Gefitinib to Support a Subcutaneous Dosing Rodent Study

High Throughput Quantification of Gefitinib-3-PROTACs and Gefitinib to Support a Subcutaneous Dosing Rodent Study
Watch Webinar

Related

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Agilely support the progression of drug candidates throughout the drug development pipeline with Waters versatile quantitative bioanalysis solutions.

Large Molecule Bioanalysis
Perform peptide, protein and oligonucleotide analysis and overcome quantitation challenges during drug development processes with Waters UPLC-MS/MS solutions for large molecule bioanalysis.

Small Molecule Bioanalysis
Accurately perform small molecule bioanalysis of drug therapeutics with Waters UPLC-MS/MS solutions, designed to maximize throughput and minimize non-specific absorption.

In Vitro ADME Analysis
Develop dependable and robust ADME assays while reducing the risk of any potential non-specific binding sensitive compound with Waters LC-MS/MS technologies and consumables for In Vitro ADME analysis.

Learn more about Emerging Modalities in DMPK Solutions.

Learn more about Emerging Modalities in DMPK Solutions.
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