In Vitro ADME Analysis 

In Vitro ADME Analysis 

Designed to support drug discovery and drug metabolism and pharmacokinetics (DMPK) laboratories, Waters ADME (Absorption, Distribution, Metabolism, and Excretion) UPLC-MS/MS Solutions simplify the process of compound method optimization, data acquisition, and results generation, enabling scientists to accelerate drug discovery support.

Designed to support drug discovery and drug metabolism and pharmacokinetics (DMPK) laboratories, Waters ADME (Absorption, Distribution, Metabolism, and Excretion) UPLC-MS/MS Solutions simplify the process of compound method optimization, data acquisition, and results generation, enabling scientists to accelerate drug discovery support.
Pipette depositing samples in a well panel
Pipette depositing samples in a well panel

Overview

Advancements in chemical library synthesis, fractional drug design, and AI modeling have resulted in a greater number and variety of compounds requiring evaluation in drug discovery, but selecting the best compounds to take forward requires rapid determination of their physical chemistry and in vitro DMPK properties. Automated mass spectrometry (MS) method generation and high-throughput LC-MS analysis are critical to successfully supporting these studies. 

With Waters In Vitro ADME Solutions, including ACQUITY Premier System with optional Open Architecture CTC PaL autosampler configuration,  Xevo TQ-S micro Tandem Quad Mass Spectrometer, and MassLynx QuanOptimize Software, your lab can automate MS method development through to data analysis and reporting, in order to optimize discovery ADME productivity.

Applications

Supporting compound evaluation in drug discovery requires the rapid generation of LC-MS/MS methods and sample analysis. Discover how Waters LC-MS/MS solutions have been optimized to efficiently and robustly support the in vitro screening challenge and incorporate acquisition modes to help gain early insight into metabolic soft spots and toxic metabolite formation.

Supporting compound evaluation in drug discovery requires the rapid generation of LC-MS/MS methods and sample analysis. Discover how Waters LC-MS/MS solutions have been optimized to efficiently and robustly support the in vitro screening challenge and incorporate acquisition modes to help gain early insight into metabolic soft spots and toxic metabolite formation.

Application Notes

Application Notes

Video: Customer Challenges & Waters Products: Cyprotex's Experience

Discover how Waters TQ-S micro helps Cyprotex in high-throughput drug testing. Hear from Hollie Adey from Cyprotex and Mark Roberts from Waters about seamless integration, superior support, and high-quality results achieved through our partnership.

Discover how Waters TQ-S micro helps Cyprotex in high-throughput drug testing. Hear from Hollie Adey from Cyprotex and Mark Roberts from Waters about seamless integration, superior support, and high-quality results achieved through our partnership.
View Video
Waters partners with a variety of instrument vendors for the versatility you need for your business.

Solutions

Waters high-throughput UPLC-MS/MS systems provide automated high-throughput analysis to support drug discovery.

Waters high-throughput UPLC-MS/MS systems provide automated high-throughput analysis to support drug discovery.

Defining compact performance - robust sensitivity beyond expectation

Defining compact performance - robust sensitivity beyond expectation
Xevo TQ-S micro

Designed with your quantitative analysis and sample throughput in mind, explore how the Xevo TQ-S micro can bring robust sensitivity to your laboratory with dependable, high-quality analytical data, injection after injection.

  • High-Throughput ADME

Maximizing throughput and ease of use for Discovery DMPK 

Maximizing throughput and ease of use for Discovery DMPK 
ACQUITY Premier System with Optional PAL3 RSI Autosampler

Maximize the sensitivity, repeatability, and robustness of your LC and LC-MS applications, better detect metal-sensitive analytes, and minimize the risk of undetected analytes with ACQUITY Premier System with optional autosampler PAL3 RSI from CTC open architecture.

  • High-Throughput ADME

Streamline quantitative data acquisition and processing 

Streamline quantitative data acquisition and processing 
MassLynx Quantitation Applications

To assist with application-specific data acquisition and transforming data into usable results, MassLynx offers application managers with specialized data processing functionalities, eliminating the need for complex time-consuming manual data review.

  • High-Throughput ADME

Quality consumables to support your success

Quality consumables to support your success
Sirocco Sample Preparation Plates

Eliminate traditional, time-consuming sample preparation methods with Sirocco Protein Precipitation Plates, the most technologically advanced 96-well protein precipitation plate on the market.

  • High-Throughput ADME

Stop looking and start seeing – no compromise required

Stop looking and start seeing – no compromise required
ACQUITY Premier Columns

Reduce the risks associated with unpredictable chromatography with ACQUITY Premier Columns with MaxPeak High Performance Surfaces (HPS) Technology, which allows you to see and do more by reducing analyte/surface interactions.

  • High-Throughput ADME

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Achieve testing efficiencies and accurate results using streamlined Waters services and support.

Your success is just a click away

Your success is just a click away
Waters Global Services

Optimize your laboratory's productivity and success with Waters Global Services. Maintain peak system performance, minimize downtime, address application challenges, and support stringent compliance requirements.

  • High-Throughput ADME

Make science more accessible with Waters Capital

Make science more accessible with Waters Capital
Payment Solutions

Maximize your lab resources and minimize risk with payment options from Waters Capital, which includes innovative solutions to upgrade aging instruments, customized support, and flexible options to bundle your complete laboratory solution in one easy monthly payment – everything you need to advance your science.

  • High-Throughput ADME

The data speaks for itself

The data speaks for itself
Comparison of method development times for QuanOptimize vs infusion-based approach.
Rapid separation of six CYP450 probe substrate major metabolites.
The fully automated QuanOptimize workflow.
MS and MS/MS spectra obtained from the positive ion ESI LC-MS/MS analysis of rat urine D6 150 mg/kg using Survey Scan acquisition of precursors of m/z=96.88.

Webinars and Resources

  • Application Notebook

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape
Download
  • Case Study

Advances in High-Throughput ADME-Tox Screening for Drug Discovery

Advances in High-Throughput ADME-Tox Screening for Drug Discovery
Download
  • Journal Citations

Addressing the Analytical Throughput Challenges in ADME Screening

Addressing the Analytical Throughput Challenges in ADME Screening
Download
  • Journal Citations

A Rapid UPLC/TQMS Methodology for the In Vitro Analysis of Pooled and Cocktail Cytochrome P450 Assays

A Rapid UPLC/TQMS Methodology for the In Vitro Analysis of Pooled and Cocktail Cytochrome P450 Assays
Download

Related

Quantitative Bioanalysis
Agilely support the progression of drug candidates throughout the drug development pipeline with Waters versatile quantitative bioanalysis solutions.

Learn more about In Vitro ADME Analysis Solutions.

Learn more about In Vitro ADME Analysis Solutions.
Pipette depositing samples in a well panel
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