Small Molecule Bioanalysis

Small Molecule Bioanalysis

Streamline drug development with reliable, sensitive, and efficient bioanalysis assays from discovery to late-stage clinical trials. Waters advanced UPLC-MS/MS solutions, with high-performance chromatography and sample preparation chemistries and consumables, together deliver dependable performance for bioanalysis of traditional small molecule drug candidates. Trust Waters to ensure consistent, high-quality quantitative data for faster, more accurate decision-making that drives drug development forward.

Streamline drug development with reliable, sensitive, and efficient bioanalysis assays from discovery to late-stage clinical trials. Waters advanced UPLC-MS/MS solutions, with high-performance chromatography and sample preparation chemistries and consumables, together deliver dependable performance for bioanalysis of traditional small molecule drug candidates. Trust Waters to ensure consistent, high-quality quantitative data for faster, more accurate decision-making that drives drug development forward.

Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.
Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.

Overview

Waters trusted sample preparation solutions, resolving chromatography columns & systems, and high-performance tandem quadrupole mass spectrometers and software facilitate the development and implementation of high-quality quantitative bioanalysis assays.

Whether you need flexibility and throughput to support discovery bioanalysis or the highest sensitivity and reproducibility to support preclinical to clinical trials, Waters UPLC-MS/MS solutions are purposely designed to address your critical quantitively bioanalysis  challenges.


Molecule background

Applications

Accurate measurement of drug and metabolite concentrations in biofluids is critical for determining a candidate’s pharmacokinetic profile in DMPK. Discover how Waters trusted sample preparation, chromatography technologies, and advanced UPLC-MS/MS systems overcome sensitivity challenges, even for low-dose, low-exposure compounds.

Accurate measurement of drug and metabolite concentrations in biofluids is critical for determining a candidate’s pharmacokinetic profile in DMPK. Discover how Waters trusted sample preparation, chromatography technologies, and advanced UPLC-MS/MS systems overcome sensitivity challenges, even for low-dose, low-exposure compounds.


Application Notes

Application Notes
Assess drug safety and determine the biotransformation of a drug compound and with quantitative bioanalysis solutions from Waters.

Solutions


Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of small molecule drug candidates in biological fluids.

Waters UPLC-MS/MS systems deliver absolute performance in separation and sensitivity for bioanalysis of small molecule drug candidates in biological fluids.

Absolute performance for lowest levels of quantification

Absolute performance for lowest levels of quantification

Expand your analytical capabilities with the compact Xevo TQ Absolute tandem quadrupole mass spectrometer, bringing superior performance, absolute sensitivity, and sustainable technology for robust quantification of drugs and metabolites.

  • High Sensitivity Bioanalysis

High performance quantitation in a compact form

High performance quantitation in a compact form

Optimize performance per square inch in routine quantitation, injection after injection, with the Xevo TQ-S micro, for exceptional analytical flexibility and sensitivity even with the most complex sample matrices.

  • High Sensitivity Bioanalysis

Dependable high performance chromatography

Dependable high performance chromatography

Optimize chromatographic resolution and speed while eliminating concerns of non-specific binding for sensitive analytes with the Waters ACQUITY Premier UPLC System and enhance overall quantitative performance in bioanalysis assays.

  • High Sensitivity Bioanalysis


The data speaks for itself

The data speaks for itself
Gefitinib – LLOQ comparison between ACQUITY Premier System with MaxPeak HPS Column vs. standard ACQUITY LC system with standard column. Gefitinib – LLOQ comparison between ACQUITY Premier System with MaxPeak HPS Column vs. standard ACQUITY LC system with standard column.
LC-MS chromatograms precursors for   Phospholipid m/z = 184 for sample extracted with the Ostro Plates show significantly less signal  (red trace) than the sample extracted using the organic solvent method (green trace). LC-MS chromatograms precursors for Phospholipid m/z=184 for sample extracted with the Ostro Plates show significantly less signal (red trace) than the sample extracted using the organic solvent method (green trace).
Simultaneous RADAR and MRM acquisition in rat urine sample following oral administration of methapyrilene at 150 mg/Kg. Peak at tR=1.7 min from the MRM transition methapyrilene 262.2→119.2 in positive ion ESI mode. Simultaneous RADAR and MRM acquisition in rat urine sample following oral administration of methapyrilene at 150 mg/Kg. Peak at tR=1.7 min from the MRM transition methapyrilene 262.2→119.2 in positive ion ESI mode.
 Xevo TQ Absolute limit of detection of Midazolam and Imipramine in rat plasma   was determined to be 0.2 pg/mL for both analytes, with the lowest level calibrator and all four QC samples at that level being detectable in all cases. Xevo TQ Absolute limit of detection of Midazolam and Imipramine in rat plasma was determined to be 0.2 pg/mL for both analytes, with the lowest level calibrator and all four QC samples at that level being detectable in all cases.

Webinars and Resources


  • Brochure

Flyer: Xevo TQ Absolute Sustainability and Cost Savings in the Lab

Flyer: Xevo TQ Absolute Sustainability and Cost Savings in the Lab
  • Application Notebook

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape

Versatile LC-MS/MS Solutions for the Evolving Bioanalysis Landscape

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Learn more about Small Molecule Bioanalysis Solutions.

Learn more about Small Molecule Bioanalysis Solutions.

Reliably and accurately quantify drug candidates in biological matrices, from transitional small molecules to novel classes (e.g., PROTACs), with Waters trusted LC-MS/MS solutions for quantitative bioanalysis.