ProteinWorks Kits
Take the complexity out of protein quantification
Sample preparation is a major source of variability in traditionally complex LC-MS/MS protein quantification workflows via the surrogate peptide approach. ProteinWorks eXpress Digest Kits simplify and accelerate protein digestion, streamlining and standardizing complex pre-analytic bioanalysis/DMPK workflows for LC-MS protein quantification in whole or immunopurified plasma.
With ProteinWorks, your lab can routinely achieve highly reproducible, accurate, and sensitive protein quantification methods. This flexible and automatable kit-based approach reduces method development time and is easily deployable from lab-to-lab and site-to-site.
ProteinWorks Kits
Specifications
Overview
- Simplifies sample preparation for protein bioanalysis/DMPK with pre-measured, lot-traceable reagents, enabling seamless method transfer across different labs and different analysts
- Enables fast, reproducible, and sensitive results for small proteins, mAbs, and ADCs
- Reduces time to result and cost of analysis with a simple, easy-to-implement, optimized protocol that minimizes or eliminates method development
- Automatable on the Hamilton STARWorks platform to maximize productivity
Recommended Use: For accurate and precise quantification of various proteins.
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Experience a streamlined, reproducible approach
Protein quantification workflows are prone to high variability due to their complex, multi-segment nature. Your assays must achieve acceptable accuracy, precision, and reproducible results to make critical research decisions. ProteinWorks eXpress Digest Kits can achieve single digit intra-kit and inter-kit reproducibility across several monoclonal antibodies.
Simplify and standardize sample preparation
Bioanalysts face many decisions when developing and deploying LC-MS protein quantification workflows. Along with multiple options, sample preparation is a major source of variability. A lack of standardization and inherent variability makes reproducible method transfer between analysts and labs challenging. ProteinWorks kits facilitate laboratory and data consistency with a standardized, kit-based approach that is easily deployable from analyst to analyst, lab to lab, and sponsor to CRO.
Achieve your desired level of sensitivity
Achieving desired detection limits can be challenging. Decisions regarding the choice of reagents, their concentrations, as well as time, temperature, and the number of steps can all affect method sensitivity. ProteinWorks offers a universal, kit-based sample preparation method with pre-weighed, lot-traceable reagents, and simple, stepwise instructions, allowing rapid quantification of infliximab down to 10 ng/mL.
Deliver optimal results with flexibility and automation
Achieving sensitivity, reproducibility, standardization, and accuracy with enough flexibility to accommodate different LC-MS protein quantification workflows can be challenging. Without the constraints of competitive kit-based approaches, ProteinWorks is optimized for a variety of different workflows, including protein bioanalysis/DMPK, allowing enough flexibility to deliver optimal results for your assays.
ProteinWorks is also automatable on the Hamilton STARWorks platform. An automated and generic kitted approach that includes a protocol and the necessary reagents can streamline method development and minimize the sample preparation complexity. The implementation of an automated liquid handler can maximize productivity, reduce human error, and improve analytical method performance.
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