Alliance iS Bio HPLC System
Intuitive simplicity for biopharma
Your biopharmaceutical quality control (QC) lab faces the relentless demand to do more with less. Trying to reduce common errors to improve efficiency and productivity, while managing the growing levels of complexity in biological samples, makes the need for intuitive simplicity in your lab more important than ever.
With the Alliance iS Bio HPLC System, featuring MaxPeak High Performance Surfaces (HPS) Technology, you can:
- Reduce unwanted interactions between your samples and the HPLC system
- Produce faster and more reproducible results with improved data integrity
- Reduce human errors up to 40%* through intuitive system intelligence
- Reduce training requirements with intuitive touchscreen operation and guided workflows
With performance features developed specifically for the biopharma laboratory, the Alliance iS Bio HPLC System will quickly become your favorite ally.
*Based on Waters market research in 2022, surveying 56 global pharma QC labs, running >25 systems.
Alliance iS Bio HPLC System
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Specifications
|
Maximum operating pressure |
12,000 psi |
|
pH range |
1 to 13 |
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Operating flow rate range |
0.001 to 10.000 mL/min |
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Injection type |
Flow-through needle |
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Sample flow path |
Inert (MaxPeak HPS Technology) |
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Sample carryover |
≤0.002% [Caffeine] under UV conditions |
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Sample compartment |
4 to 40 °C |
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Pump options |
Quaternary |
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Solvent conditioning |
Passive pre-heating |
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Column tracking |
Yes, with RFID enabled eConnect Waters Columns |
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Column capacity |
1 column up to 300 mm length, up to 8 mm internal diameter (I.D) |
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Maximum sample capacity (any three of the following) |
48-position, 2.00-mL vial holder 54-position, 2.00-mL vial holder 96-well plate 384-well plate 48-position, 0.65-mL micro-centrifuge tube plate 24-position, 1.50-mL micro-centrifuge plate |
|
Detector options |
TUV Detector |
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Informatics compatibility |
Empower Chromatography Data System (CDS) (Feature Release 4 with Windows 10 and later) |
|
Physical Specifications |
Height: 74.2 cm (29.23 in.) Width: 49.9 cm (19.64 in.) Depth: 63.5 cm (24.99 in.) Weight: 72.5 kg (160.0 lbs.) |
Overview
- Reduce analyte/surface interactions with MaxPeak HPS Technology for exceedingly bio-inert separations to improve sample recovery, reproducibility, and sensitivity
- Withstand deterioration with corrosion-resistant, bio-compatible materials of construction for maximum system robustness
- Improve performance with an enhanced system design that intuitively prevents common errors
- Drive workflow efficiency with intuitive touchscreen operation and guided workflows for fast, simple guidance at the point of need
- Minimize system downtime using guided maintenance and troubleshooting
- Simplify method transfer with the Intelligent Method Translator App (iMTA)
- Expand MaxPeak HPS Technology with Waters QuanRecovery Vials and MaxPeak Premier HPLC Columns with e-Connect Technology, for an exceedingly bio-inert solution across all sample touchpoints
Recommended Use: For biopharma QC labs with a drive to reduce human errors and unexpected downtime.
Your biopharma lab ally - exceedingly inert for bioseparations
Non-specific adsorption (NSA) of metal-sensitive compounds, such as oligonucleotides and phosphopeptides, is an unpredictable challenge leading to long column passivation times, chromatography with large relative standard deviations (RSDs), and broad peaks that can be challenging to detect.
The Alliance iS Bio HPLC System is a step-change above traditional biocompatible systems. With corrosion-resistant construction materials to maximize system robustness under high salt extremes, and MaxPeak HPS Technology to minimize non-specific adsorption of metal-sensitive analytes without complicated mobile phases or laborious methods, you experience:
- Faster, more reproducible, and accurate data integration
- Shorter time from sample to result by eliminating the need for system conditioning
- The ability to meet compliance standards with higher quality data
Modernize your bioseparations methods
Size-exclusion chromatography (SEC) is a powerful separations technique for monoclonal antibody (mAb) characterization and quality control. With the Alliance iS Bio HPLC System, you can confidently run your legacy mAb separations while meeting system suitability criteria for compendial methods and improving resolution due to lower system dispersion.
In addition, acidic peptides and phosphopeptides can be very challenging to separate using conventional HPLC systems. The Alliance iS Bio HPLC System featuring MaxPeak HPS Technology is designed to minimize unwanted protein interactions with the system while improving recovery, retention time consistency, and peak shapes. With the Alliance iS Bio HPLC System, you can reduce analysis times and save resources by scaling your peptide methods to 2.5 µm from 5 µm chemistries.
Intuitive innovation to support your compliance needs
Your systems need to support both legacy and new methods that can be operated repeatably anywhere in the world while meeting regulatory requirements. These requirements can place a large burden on your analysts, but failing to perform necessary tasks could put your organization at risk.
One of the advanced tools available with the Alliance iS Bio HPLC System is the Intelligent Method Translator App (iMTA), which will assist you with method migration from other systems, automatically and compliantly. Additionally, when coupled with Empower Software Solutions and eConnect HPLC Columns, analysts gain access to new features:
Method Matching warns users when attempting to use an unsupported method on the system
Empower System Audit Trail automatically captures installation of and modifications to the system and system software for added traceability
Automated column history tracking
waters_connect System Monitoring for real-time fleet management
Boost your productivity with systems built to perform
Developed for QC labs, the Alliance iS Bio HPLC System also includes a range of new and unique features that deliver improved performance, helping reduce the incidence of failed runs as a result of poor system performance:
Class-leading carryover and injection precision
Robust performance when operating at extremes of the column heater cooler and sample manager temperature ranges
Faster detector warm-up time and reduced drift
Redesigned check valves and mixer for increased performance and robustness
Tool-free, finger-tight fittings to reduce errors and leaks
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