Peptide Standards and Kits
Benchmark and validate your peptide columns with ease
Verify your column performance upon receipt and monitor column condition over column lifetime to save valuable research and development time with Waters Peptide Standards. Run your peptide separations on any UPLC, HPLC, or LC-MS system with ease and confidence using these specifically formulated, prepackaged standards. Prepackaged in Waters vials, Peptide Standards eliminate the need to prepare complex mixtures – providing ease of use while minimizing sample loss and discrepancies.
Waters Peptide, Phosphopeptide, and Protein Digest Standards were designed to complement Waters Peptide Columns and system solutions to help evaluate, validate, and benchmark system performance. Waters manufacturing and quality control testing procedures ensure each standard is batch tested with the same functional specification test and column on relevant systems, so you’ll achieve consistent batch-to-batch and column-to-column performance regardless of application demands.
Peptide Standards and Kits
Specifications
Overview
Verify the performance of your column upon receipt to ensure consistent batch-to-batch and column-to-column performance
Monitor the condition of your columns to extend column lifetime
Gain confidence in in your analysis with peptide standards that are quality controlled (QC) per lot to guarantee performance
Increase productivity and reduce system downtime with ready-to-use peptide standards that can be directly solubilized
Recommended Use: For the verification of LC and LC-MS instrumentation and column performance for peptide analysis.
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Quantitative peptide standards
When accuracy is critical, Waters offers several quantitative peptide standard mixes specifically designed to be run before your analysis to ensure LC or LC-MS system confidence. They can also be spiked into complex samples to help with analytical accuracy. The Quantitative Peptide Retention Standard is useful during calibration, development, and troubleshooting of chromatographic separations, ensuring confidence in results. In addition, the Hi3 line of Peptide Standards provides MS users with a purified sample mix of the 6 top ionizable peptides in Phosphorylase B and E.Coli.
Reversed-phase peptide standards
The ability to qualify and troubleshoot your bioseparation with a standard that is similar to your samples is critical. The Cytochrome C Digestion Standard is part of a line of qualitative digestion standards used for performance evaluation of HPLC and UPLC columns for peptide separation. This standard is used to benchmark the ACQUITY UPLC, XBridge, and XSelect CSH Peptide Columns. In addition, the MassPREP Peptide Mixture is a complex mix of nine carefully selected peptides with a broad range of polarities and isoelectric points used for the evaluation and troubleshooting of HPLC and UPLC columns and systems dedicated for peptide separations.
Phosphopeptide enrichment and standards
Phosphorylation is a prevalent post-translational modification (PTM) for regulating protein function. The MassPREP Phosphopeptide Enrichment Kit provides selective enrichment of phosphopeptides from complex samples through affinity-based SPE. In addition, Waters offers a suite of standards, ranging from simple to complex, that consist of highly purified sample sets of synthetic phosphopeptides used to optimize phosphopeptide detection in LC-MS, LC-UV, and MALDI-MS analyses.
Simple digestion standards
Protein digestions can be very time consuming and irreproducible. Waters offers a variety of protein digests valuable to use as complex biological matrices for proteomic evaluations as well as for performance evaluation of HPLC, UPLC columns and LC-MS instrumentation. They are especially useful in positive ion mode evaluations for sensitivity, resolution, and mass measurement accuracy on nanoACQUITY and QToF based systems.
mAb digestion standards
Peptide level analysis of proteins by LC-MS is one of the primary approaches for the characterization of biopharmaceuticals—in particular, monoclonal antibodies (mAbs). In such an analysis, it is possible to acquire peptide mass information and quickly confirm protein sequence, post-translation modifications, and degradation-related critical quality attributes. To support this application area, Waters has commercialized several digestion standards, such as the mAb Tryptic Digest Standard, and the mAb Subunit Standard, which can be used in the benchmarking of LC-MS techniques, proficiency testing among different instruments and laboratories, and system suitability when performing peptide level protein analysis.
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