Mapping phosphorylation of peptide biomarkers corresponding with glioblastoma tumours using DDA and a novel MRT mass spectrometer

Library Number:
LITR135134879
Part Number:
720008385EN
Author(s):
Matthew E. Daly1, Lee A. Gethings1, Christopher J. Hughes, Richard Lock, Hamida Mussa, Nelofer Syed
Source:
Waters, Imperial College London
Content Type:
Literature
Content Subtype:
Brochures

Phosphorylation plays a key role in activation of specific pathways in vivo, which has also been demonstrated to play a part in cancer development. Here, we utilise Data Dependent Acquisition with fast scan times of 20Hz MSMS and mass resolution up to 100,000 FWHM on the Xevo MRT to definitively map and localise these post-translational modifications in treated and untreated human glioblastoma cell lines.


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