Intact Mass Analysis

Intact mass analysis of traditional and emerging biotherapeutic modalities:

• Streamline mass confirmation and purity determination of biomolecules, including proteins, peptides, oligonucleotides, and conjugates
• Increase your laboratory’s capacity for Intact Mass analysis with intelligent automated deconvolution
• Reduce time to result and increase flexibility with automated acquisition and processing
• Utilize the universal BayesSpray algorithm or widely used average mass MaxEnt1 deconvolution algorithms 
• Support for both MS- and UV-based quantification of impurities and impurity identification
• Supports high-capacity, high-throughput mass confirmation and purity determination of hundreds of unique biomolecules per day

Peptide mapping

The peptide mapping workflow automates the analysis of digested protein-based therapeutics by MS, DDA MS/MS, and DIA MSE-based acquisition.

• Peptide identification based on accurate mass and fragment confirmation
• Sequence coverage at peptide and fragment levels
• Assignment of protein modificaitons and calculation of % modificiaton levels
• Collect m/z, retention time, and charge state response information to build libraries for targeted analysis by Peptide MAM

Peptide MAM​

The waters_connect Peptide MAM application provides an automated workflow for product quality attribute monitoring, ID confirmation, and new peak detection-based purity assays​:

• Integrate data acquisition, system suitability, data review, and reporting with a simple graphical workflow design for efficient data review

• Populate the targeted attribute list directly from the waters_connect scientific library, import file, or via manual entry

• Avoid missed peaks and improve quantification with advanced RT alignment tools

• Enhance productivity with robust new peak detection of potential impurities, providing high sensitivity with low false positive detection rates 

Learn how to effectively implement MAM in a regulated QC enviroment in this webinar, presented in collaboration with Quality Assistance. 

Oligonucleotide Sequencing

The new CONFIRM Sequence application is the first purpose-built workflow to accelerate the characterization of oligonucleotides.

• Streamline nucleic acid sequence confirmation and impurity characterization with a dedicated workflow.
• Improve analytical efficiency with rapid analysis and calculation of sequence coverage from multiple targeted (MS/MS) or untargeted (MS^E) experiments.
• Increase confidence in results with automated modification localization.
• Reduce time spent on data interrogation with unique data visualization tools and comprehensive raw data review features.
• Maintain regulatory requirements with the complaint ready waters_connect platform.